Drug Transporters
Molecular Characterization and Role in Drug Disposition
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Beschreibung
A comprehensive guide to drug transporters that influence theabsorption, distribution, and elimination of drugs in thebody
The development of powerful expression cloning and genome analysistechniques has facilitated the molecular identification andcharacterization of numerous transporters that play a crucial rolein drug disposition. Explaining the principles of drug transportand the associated techniques, Drug Transporters: MolecularCharacterization and Role in Drug Disposition:
* Provides a comprehensive overview of drug transporters
* Includes specific descriptions of transporter families, includingsubstrate and inhibitor specificity, subcellular and tissuelocalization, mechanisms governing transport, species differences,the clinical implications of these transporters in human physiologyand disease, and their role in drug distribution, elimination, andinteractions in drug therapy
* Describes transporter-mediated drug disposition, a newly emergingfield in drug therapy
* Gives a comprehensive summary of drug transport across biologicalmembranes
* in the liver, brain, kidney, and intestine
* Provides balanced coverage of mechanistic aspects and functionaloutcomes
* Features chapters contributed by distinguished scientists in theirspecialty areas
* Provides sufficient detail to enable non-specialists to understandthe principles and techniques
This authoritative guide is a practical hands-on desk reference forresearchers in academia and the pharmaceutical industry andscientists in government agencies. It is also an excellent text forgraduate-level courses in the pharmaceutical and pharmacologyfields.
Autor*in
Guofeng You
Themen in »Drug Transporters«
Arzneimittel Biowissenschaften Cell & Molecular Biology Chemie Chemistry Life Sciences Medical Science Medizin Molekularbiologie Pharmaceutical & Medicinal Chemistry Pharmacology & Pharmaceutical Medicine Pharmakologie u. Pharmazeutische Medizin Pharmazeutische Chemie Pharmazeutische u. Medizinische Chemie Zell- u. Molekularbiologie