Fundamentals of Early Clinical Drug Development
From Synthesis Design to Formulation
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Beschreibung
An informative look at the intricacies of today's drug developmentprocess
Once a discovery organization has identified a potential new drugcandidate, it is the daunting task of synthetic organic chemists toidentify the chemical process suitable for preparation of thiscompound in a highly regulated environment. Only through amulti-layered chemical process that takes into account such factorsas safety, environmental considerations, freedom to operate andcost-effectiveness can researchers begin to refine the drug interms of quality and yield.
This book covers both recent advances in the design and synthesisof new drugs, as well as the myriad other issues facing a new drugcandidate as it moves through the development process. Utilizingrecent case studies, the authors provide valuable insights into thecomplexities of the process, from designing new syntheticmethodologies and applying new automated techniques for findingoptimal reaction conditions to selecting the final drug form andformulation.
Both novice and active researchers will appreciate the inclusion ofchapters on such diverse topics as:
* Cross-coupling methods
* Asymmetric synthesis
* Automation
* Chemical Engineering
* Application of radioisotopes
* Final form selection
* Formulations
* Intellectual property
A wealth of real-world examples and contributions from leadingprocess scientists, engineers, and related professionals make thisbook a valuable addition to the scientific literature.
Autor*in
Ahmed F. Abdel-Magid
Themen in »Fundamentals of Early Clinical Drug Development«
Chemie Chemistry Drug Discovery & Development Organic Chemistry Organische Chemie Wirkstoffforschung u. -entwicklung
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"This book will give a lot of pleasure and information to themedicinal chemist, the synthetic organic chemist, and anyoneinvolved in taking a drug candidate to the stage of pharmaceuticalformulation." (Journal of Medicinal Chemistry, December 28,2006)
'...this is an excellent book...It is highlyrecommended to all scientists involved in developing new processesfor APIs.' (Organic Process Research and DevelopmentJournal, July 2007)
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