The hERG Cardiac Potassium Channel

Beschreibung

This book draws together contributions from basic, pharmaceuticaland clinical sciences aimed at a better understanding of thestructure and function of hERG and the molecular basis for compoundbinding. It features regulatory authority perspectives on preferredpreclinical test systems and includes topics on hERG channelgating, regulation of functional expression, pharmacologicalproperties of hERG/IKr channels, drug-induced long QT syndrome andpreclinical evaluation and regulatory recommendations for assessingQT prolongation risks. Better understanding of the role of the hERG channel indrug-induced cardiac arrhythmias should ultimately lead to thedevelopment of important, new and safer medicines.

Autor*in

Derek J. Chadwick

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Biowissenschaften Cell & Molecular Biology Life Sciences Molekularbiologie Zell- u. Molekularbiologie

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"This is a fantastic collection of hERG channel-relatedpapers, with discussion from experts in the field raising questionsyet to be answered." (The Biochemist, 1 December2012)"...a useful reference for current literature and developmentson the cardiac hERG potassium channel. No other books are currentlyavailable on the subject." (Doody's Health Services)
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