Aging and the Heart
A Post-Genomic View
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Beschreibung
Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities will be undertaken.
José Marín-García is Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey.
Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging is discussed. The work has been enabled by the availability of the Human Genome Project, and an ever increasing number of animal models as well as new and exciting molecular technologies. It can now be genuinely stated that the unraveling of the underlying basic mechanisms of cardiac aging have begun. The book also includes a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities are undertaken.
Includes 40 illustrations
Autor*in
José Marín-García
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Cardiac Cardiologist Gerontologist Molecular cardiovascular hypertension
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From the reviews:
"A comprehensive and authoritative book about cardiac senescence in the postgenomic period. … The book is extensively referenced and thoroughly researched. The bibliographies provided after each chapter are exhaustive, and the end of the book includes an ample glossary section defining the plethora of acronyms used throughout." (M. Saleem Seyal, JAMA, Vol. 300 (9), 2008)
“This is a comprehensive review of basic science research in the field of aging in the context of clinically relevant cardiovascular disorders. … It is intended for both basic scientists and clinicians with … some experience in biochemistry, molecular and cell biology, and genetics who are interested in cardiovascular aging. … The best features of this book are its comprehensiveness, with its numerous sources of research, and its integration of basic science research into relevant clinical topics.” (Arindam Banerjee, Doody’s Review Service, January, 2010)()