Modulation of Protein Stability in Cancer Therapy
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Beschreibung
This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.
Chapters focus on the cellular and molecular mechanisms of various small-molecule compounds and inhibitors that target proteins that regulate the proteasome, ubiquitin ligases, ubiquitination pathway, and aggresome pathway in cancer
Autor*in
Kathleen Sakamoto
Themen in »Modulation of Protein Stability in Cancer Therapy«
BRCA anemia carcinogenesis enzymes prostate cancer protein proteins