Computational Methods for Protein Structure Prediction and Modeling
Volume 2: Structure Prediction
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Beschreibung
Volume 2 of this two-volume sequence focuses on protein structure prediction and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well as structure prediction as a systems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics.
Presents a comprehensive overview of protein structure prediction methods Each chapter is a self contained review designed to cover (1) definition of the problem and an historical perspective, (2) mathematical or computational formulation of the problem, (3) computational methods and algorithms, (4) performance results, (5) existing software packages, and (6) strengths, pitfalls, challenges, and future research directions Covers topics from De novo methods of protein structure prediction to structure based drug design
This volume focuses on protein structure prediction methods and describes homology-based structure modeling, fold recognition of globular proteins, ab initio protein structure prediction, structure prediction of membrane proteins, prediction of structures of protein complexes, protein structure-based drug design, and structure prediction as a systems problem. It also contains a chapter listing Internet resources for protein structure/function characterization.
Autor*in
Ying Xu
Themen in »Computational Methods for Protein Structure Prediction and Modeling«
membrane proteins protein complexes protein structure protein structure prediction protein threading proteins Proteomics