Gene Expression and Regulation
Buch in deiner Nähe kaufen
Beschreibung
This book offers a comprehensive look into the science of
gene expression and regulation. Focusing on topics such as
actions of nuclear receptors, RNA processing, and DNA
methylation and imprinting, Gene Expression and
Regulation is edited by a leading biologist and includes
contributions by experts in the field.
Presented in the following five sections, this book covers a
full spectrum of topics: The History; The Machinery; The Regulators;
The Genome; and Special Topics. The Machinery section
covers the transcriptional apparatus and general
transcription factors. The Regulators section examines
selected gene-specific transcription factors important to
regulating gene expression. The Genome section covers
issues relevant to the behavior of the genome in relation to
gene regulation. The Special Topics section discusses
several selected topics ranging from bacterial and plant gene
expression to DNA topology and interference RNA. The
book’s focus is on scientific concepts and issues, rather than
specific organisms or experimental approaches.
Complete with more than 100 illustrations, Gene Expression
and Regulation provides biologists with concise and
comprehensive research outlined in chapters including:
• DNA Topology and Transcription
• Gene Expression in Plants
• Chromatin and Chromatin Remodeling
• Core Promoter Elements
• Bacterial Gene Regulation
• Transcription Factor Dynamics
Jun Ma, PhD, is an Associate Professor, Division of
Developmental Biology, Cincinnati Children’s Hospital Research
Foundation, University of Cincinnati College of Medicine,
Cincinnati, Ohio, USA.
All genes must be expressed to exhibit their biological activities. How genes are expressed and regulated is a central question in molecular biology and our knowledge in this area has been expanding enormously in recent years. The complexity of gene regulation is compounded by the fact that gene activities reach every comer of biology. Transcription is universally the first step toward expressing a gene. It is a highly regulated process. Understanding the molecular mechanisms of transcription regulation is of fiindamental importance. For protein-coding genes, post-transcriptional steps, including pre-mRNA processing, mRNA transport and translation, can also play important roles in regulating gene expression. To contain the scope of this book, we will focus primarily on RNA polymerase II transcription and regulation. We will explore not only the biochemical basis of transcription but also the biological consequences of, and biological influences on gene transcription. The book is composed of 35 individual review articles written by authorities in the field. The chapters are organized into five sections: The History, The Machinery, The Regulators, The Genome, and Special Topics. The History section contains one chapter, written by James Goodrich and Robert Tjian, who provide an excellent historical perspective and overview of the transcription process. The Machinery section has six chapters that cover essential topics on the transcriptional apparatus, general cofactors, chromatin structure, and core promoter structure.
Provides comprehensive coverage of the science of gene expression and regulation
Edited by an expert in the field
Concentrates on concepts and issues, rather than specific organisms or experimental approaches
Autor*in
Jun Ma
Themen in »Gene Expression and Regulation«
Activation Arabidopsis thaliana Chromatin DNA Jun Ma RNA regulation tissue